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Does excessive adenosine 5'-triphosphate formation in cells lead to malignancy? A hypothesis on cancer
Published in Churchill Livingstone
Volume: 48
Issue: 6
Pages: 473 - 476
In biological systems, adenosine triphosphate (ATP) is the principal contributor of free energy necessary for anabolic reactions and is also a precursor of nucleic acids. Moreover, active transport of metabolites into cells is also driven by hydrolysis of ATP. So, a cell may grow, multiply and ultimately turn malignant when it has been transformed in such a manner that it produces excess ATP as compared with its usual metabolic demand. Recent studies have indicated that mitochondrial complex 1 and the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GA3PD) may be critically altered specifically in malignant cells. So, we further propose that this excessive ATP formation may be due to altered mitochondrial complex I and GA3PD of malignant cells.
About the journal
JournalMedical Hypotheses
PublisherChurchill Livingstone