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Digital Camera-Based Spectrometry for the Development of Point-of-Care Anemia Detection on Ultra-Low Volume Whole Blood Sample
A HALDER, P K SARKAR, P PAL, S CHAKRABARTI, P CHAKRABARTI, D BHATTACHARYYA, , S K PAL
Published in Institute of Electrical and Electronics Engineers Inc.
2017
Volume: 17
   
Issue: 21
Pages: 7149 - 7156
Abstract
Objective of this paper: Early detection of anemia (low hemoglobin count) at point-of-care (PoC) in a low resource setting is challenging given the associated capital and recurring costs of the device. In this paper, we have developed a faster and reliable method to screen the hemoglobin level in the whole blood in a resource limited point of care setting. We have also investigated a simple scattering-based technique to predict the overall morphology of the red blood cells. Methods: In this paper, we have developed and validated a digital camera-based spectrometer for the early detection of anemia with the whole blood of 10-μL volume in a low resource PoC setting. The developed device consists of two LEDs [Green (570 nm) and Red (631 nm)], a web camera, a fluid sensing chamber (cuvette holder), and associate electronics. Validation of Beer-Lambert law using the blood of various degree of dilution has been achieved in this in vitro experiment. Major results: A significant number of human subjects (300) having a wide range of hemoglobin counts in a hospital is tested and found to reproduce results from a gold standard automated hematology analyzer. Our developed microcuvette requires only 10-μL unprocessed whole blood sample for the device. Conclusions: The device is expected to serve as a minimally invasive e-health care device for the anemia screening in any resource-limited point of care setting. © 2001-2012 IEEE.
About the journal
JournalData powered by TypesetIEEE Sensors Journal
PublisherData powered by TypesetInstitute of Electrical and Electronics Engineers Inc.
ISSN1530-437X