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Diaryliodonium salt as oxidant in sp3 C-H activation and synthesis of quinazolin-4(3H)-ones
Das Adhikary N., Mandal S., Jana A.,
Published in Elsevier B.V.
2022
Volume: 4
   
Abstract
Reactions of 2-aminobenzamides with diaryliodonium salts in N,N-dimethylacetamide (DMA) led to the formation of unexpected product quinazoline-4(3H)-one derivatives instead of the desired N-arylated 2-aminobenzamides. Most likely the diaryliodonium salts activated the sp3 C-H of N-methyl group of DMA through oxidation thereby produced an iminium species, the reaction of which with 2-aminobenzamides caused the annulation. © 2021 The Author(s)
About the journal
JournalResults in Chemistry
PublisherElsevier B.V.
ISSN22117156
Open AccessNo