Automated, efficient and accurate classification of skin diseases using digital images of skin is very important for bio-medical image analysis. Various techniques have already been developed by many researchers. In this work, a technique based on meta-heuristic supported artificial neural network has been proposed to classify images. Here 3 common skin diseases have been considered namely angioma, basal cell carcinoma and lentigo simplex. Images have been obtained from International Skin Imaging Collaboration (ISIC) dataset. A popular multi objective optimization method called Non-dominated Sorting Genetic Algorithm - II is employed to train the ANN (NNNSGA-II). Different feature have been extracted to train the classifier. A comparison has been made with the proposed model and two other popular meta-heuristic based classifier namely NN-PSO (ANN trained with Particle Swarm Optimization) and NN-GA (ANN trained with Genetic algorithm). The results have been evaluated using various performances measuring metrics such as accuracy, precision, recall and F-measure. Experimental results clearly show the superiority of the proposed NN-NSGA-II model with different features. © 2017 IEEE.