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Design of a new foldamer turn-linker-turn in acyclic hexapeptides and formation of channels through self-assembly
A DUTTA, S KAR, P KOLEY,
Published in ELSEVIER SCIENCE BV
2009
Volume: 917
   
Issue: 43499
Pages: 110 - 116
Abstract
Single crystal X-ray diffraction studies and solvent dependent NMR titration reveal that the designed peptides I and II, Boc-Xx(1)-Aib(2)-Yy(3)-NH(CH2)2NH-Yy(3)-Aib(2)-Xx(1)-Boc, where Xx and Yy are Ile and Leu in peptide I and Leu and Val in peptide II, respectively, fold into a turn-linker-turn (T-L-T) conformation both in the solid state and in solution. In the crystalline state the T-L-T foldamers of peptide I and II self-assemble to form a three-dimensional framework of channels. The insides of the channels are hydrophilic and found to contain solvent CHCl3 hydrogen bonded to exposed C{double bond, long}O of Aib located at the turn regions. © 2008 Elsevier B.V. All rights reserved.
About the journal
JournalData powered by TypesetJournal of Molecular Structure
PublisherData powered by TypesetELSEVIER SCIENCE BV
ISSN0022-2860
Open AccessNo