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Dendritic cells subsets mediated immune response during Plasmodium berghei ANKA and Plasmodium yoelii infection
T KESWANI, A SENGUPTA, S SARKAR,
Published in Academic Press
2015
PMID: 25792277
Volume: 73
   
Issue: 2
Pages: 198 - 206
Abstract
The roles of dendritic cells (DCs) in mediating immunity against Plasmodium infection have been extensively investigated, but immune response during pathogenesis of malaria is still poorly understood. In the present study, we compared the splenic DCs phenotype and function during P. berghei ANKA (. PbA) or P. yoelii (. P. yoelii) infection in Swiss mice. We observed that PbA-infected mice developed more myeloid and mature DCs capable of secreting IL-12, while P. yoelii-infected mice had more plasmacytoid and immature DCs secreting higher levels of IL-10. Expression of FoxP3, IL-17, TGF-β and IL-6 were also different between these two infections. Thus, these results suggest that the phenotypic and functional subsets of splenic DCs are key factors for regulating immune responses to PbA and P. yoelii infections. © 2015 Elsevier Ltd.
About the journal
JournalCytokine
PublisherAcademic Press
ISSN1043-4666
Open AccessNo