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Deciphering parameter sensitivity in the BvgAS signal transduction
T MAPDER, S TALUKDER, S CHATTOPADHYAY, S K BANIK
Published in Public Library of Science
2016
Volume: 11
   
Issue: 1
Abstract
To understand the switching of different phenotypic phases of Bordetella pertussis, we propose an optimized mathematical framework for signal transduction through BvgAS twocomponent system. The response of the network output to the sensory input has been demonstrated in steady state. An analysis in terms of local sensitivity amplification characterizes the nature of the molecular switch. The sensitivity analysis of the model parameters within the framework of various correlation coefficients helps to decipher the contribution of the modular structure in signal propagation. Once classified, the model parameters are tuned to generate the behavior of some novel strains using simulated annealing, a stochastic optimization technique. © 2016 Mapder et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
About the journal
JournalPLoS ONE
PublisherPublic Library of Science
ISSN1932-6203
Open AccessYes