Header menu link for other important links
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts
S. Bhattacharyya, D. Md Sakib Hossain, S. Mohanty, G. Sankar Sen, , S. Banerjee, J. Chakraborty, K. Das, D. Sarkar, T. DasShow More
Published in
PMID: 20305684
Volume: 7
Issue: 4
Pages: 306 - 315
Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion. CD8 cytotoxic T lymphocytes (CTLs) are involved in antigen-specific tumor destruction and CD4 T cells are essential for helping this CD8 T cell-dependent tumor eradication. Tumors often target and inhibit T-cell function to escape from immune surveillance. This dysfunction includes loss of effector and memory T cells, bias towards type 2 cytokines and expansion of T regulatory (Treg) cells. Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts. Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses. We observed severe loss of both effector and memory T-cell populations, downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors. Curcumin, in turn, prevented this loss of T cells, expanded central memory T cell (T CM)/effector memory T cell (T EM) populations, reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts. Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor (TGF)-Β and IL-10 in these cells. Curcumin, however, inhibited the suppressive activity of Treg cells by downregulating the production of TGF-Β and IL-10 in these cells. More importantly, curcumin treatment enhanced the ability of effector T cells to kill cancer cells. Overall, our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. © 2010 CSI and USTC. All rights reserved.
About the journal
JournalCellular and Molecular Immunology