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Cross-linked methyl cellulose/graphene oxide rate controlling membranes for: In vitro and ex vivo permeation studies of diltiazem hydrochloride
G SARKAR, N R SAHA, I ROY, A BHATTACHARYYA, A ADHIKARI, M BHOWMIK, M BOSE, ,
Published in Royal Society of Chemistry
2016
Volume: 6
   
Issue: 42
Pages: 36136 - 36145
Abstract
Permeability characteristics of the anti-hypertensive drug, diltiazem hydrochloride, from uncross-linked and cross-linked methylcellulose (MC)/graphene oxide (GO) rate controlling membranes (RCMs) were investigated. The MC/GO membranes were cross-linked with different concentrations of glutaraldehyde (GLA) to examine the effect of cross-linking on the permeability characteristics. The ATR-FTIR spectra, along with solubility resistance, swelling studies, the molar mass between cross-links, and moisture absorption of cross-linked RCMs over the uncross-linked RCM confirmed the cross-linking between MC and GO. The cross sectional view of cross-linked and uncross-linked RCMs, as observed by SEM, showed that the porous and fibrillose structure of the uncross-linked RCM was disrupted after cross-linking. The cross-linked RCMs showed improved mechanical and thermal properties compared to the uncross-linked RCMs. In vitro and ex vivo drug release was found to depend on the concentration of the cross-linker, which suggests that drug delivery is controlled by the cross-link density of RCM. © The Royal Society of Chemistry 2016.
About the journal
JournalData powered by TypesetRSC Advances
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN2046-2069
Open AccessNo