Header menu link for other important links
Conformational alteration of bradykinin in presence of GM1 micelle
Published in Academic Press Inc.
PMID: 14985092
Volume: 315
Issue: 4
Pages: 866 - 871
We report here the interaction of bradykinin with ganglioside GM1 by circular dichroism, steady-state fluorescence, and one-dimensional 1H NMR spectroscopy. Circular dichroism spectroscopy is indicative of a turn formation of bradykinin backbone in the presence of GM1 micelle. The fluorescence quenching efficiencies of iodide and acrylamide are substantially reduced, indicating a shielding of phenylalanine residue of bradykinin from aqueous environment. Significant line broadening of NMR resonances of bradykinin, suggestive of motional restriction, is observed. © 2004 Elsevier Inc. All rights reserved.
About the journal
JournalBiochemical and Biophysical Research Communications
PublisherAcademic Press Inc.
Open AccessNo