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Comparison of the protection afforded by a crude extract of phyllanthus emblica fruit and an equivalent amount of synthetic ascorbic acid against the cytotoxic effects of cesium chloride in mice
Published in Informa Healthcare
Volume: 31
Issue: 2
Pages: 116 - 120
The relative effects of a crude aqueous extract from Phyllanthus emblica fruit and an equivalent amount of synthetic ascorbic acid (vitamin C) in reducing the clastogenic action of cesium chloride (CsCl) in vivo on mice bone marrow cells were compared. CsCl-induced chromosomal aberrations were observed in the mice 24 hours after exposure in frequencies that were direcdy proportional to the dose administered. Neither ascorbic acid nor the fruit extract induced chromosomal aberrations in high frequency even after treatment for seven days. On the other hand, oral administration of either ascorbic acid or Phyllanthus emblica extract for seven days prior to exposure to CsCl for 24 hours reduced the frequency of chromosomal aberrations. This protective action of orally-administered Phyllanthus extract against damage induced by CsCl is of considerable importance in view of the possible entry of Cs into edible plants from soil and subsequently into the foodchain following radioactive fallout. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
About the journal
JournalPharmaceutical Biology
PublisherInforma Healthcare