The effects of liquid flow rate, coil diameter, pseudo plasticity of the liquids on the frictional pressure drop for the flow through helical coils have been reported through experimental investigation. Numerical modeling is carried using Fluent 6.3 software to find its applicability in the flow system. The Computational Fluid Dynamics (CFD) simulations are carried out using laminar non-Newtonian pseudo plastic power law model for laminar flow and k-ε model for turbulent flow for water. Water and dilute solution of Sodium Carboxy Methyl Cellulose (SCMC) as a non-Newtonian pseudo plastic fluid used for the study. Both hexahedral and tetrahedral grids are used for this simulation. The CFD results show the very good agreement with the experimental values. The comparison of the non-Newtonian liquid flow and water are also reported. © 2015, The Institution of Engineers (India).