Studies have been carried out on the effect of L ascorbic acid supplementation on the cadmium toxicity in rats. Cadmium toxicated rats showed drastic decrease in the growth rate and became severely anaemic with diminished level of L ascorbic acid in urine, and supplementation of L ascorbic acid to this group of animals could reverse these effects. There was a marked decrease in the concentration of L ascorbic acid in the liver of rats maintained on cadmium supplemented basal diet and administration of L ascorbic acid to this group brought the tissue reserve to the normal level. Normal histological pattern of the liver tissue of rats was completely disturbed under cadmium toxicity. In the liver of cadmium toxicated rats the rate of L ascorbic acid synthesis was greatly reduced with an increased catabolic breakdown of L ascorbic acid. The enzyme responsible for L xylulose biosynthesis in the kidney tissue of rats was markedly inhibited by cadmium toxicity.