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Brain 5-hydroxytryptamine and plasma testosterone in l-tryptophan treated rats
N M BISWAS, R MAZUMDER, S K BHATTACHARYA, T K DAS
Published in MARCEL DEKKER INC
1985
Volume: 11
   
Pages: 131 - 137
Abstract
Loading of L-tryptophan för 7 and 21 days increased brain 5-hydroxytryptamine (5-HT) level which was associated with decreased plasma testosterone level. Human chorionic gonadotropin (HCG) administration in L-tryptophan treated rats för 21 days increased the plasma testosterone level in spite of increased brain 5-HT level. These results suggest that brain 5-HT exerts an inhibitory influence on testicular steroidogenesis by modulating the gonadotropin-releasing-factor (GnRH) release and thence pituitary gonadotropins. © 1985, Informa UK Ltd. All rights reserved.
About the journal
JournalEndocrine Research
PublisherMARCEL DEKKER INC
ISSN0743-5800