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Biopolymer based interfacial tissue engineering for arthritis
K GHOSAL, R KHANNA,
Published in Springer International Publishing
2018
Pages: 67 - 88
Abstract
In addition to trauma or severe injury, osteoarthritis (OA) and rheumatoid arthritis (RA) cause joint damage where both the articular cartilage and the underlying subchondral bone become damaged and have become a serious issue globally. Despite the progress in the tissue engineering field, osteochondral tissue regeneration is still challenging to researchers due to the presence of progressive gradient material composition and complex physiological properties. Presently, interfacial tissue engineering (ITE), a modern technique to regenerate biphasic or multiphasic complex tissue interfaces such as bone-cartilage, muscle-tendon, and tendon/ligament-bone has become more attractive in the tissue engineering field. Biopolymer based scaffolds have gained tremendous attraction over other materials in the tissue engineering field owing to its ease of synthesis and modification, biodegradability, biocompatibility and less immunogenicity. Therefore, it is necessity to know about various biopolymers and different strategies to fabricate osteochondral constructs for ITE. In this chapter, we elaborately discuss the anatomy of the osteochondral interface followed by different biopolymers and osteochondral construct fabrication techniques used for osteochondral tissue regeneration by ITE. © Springer International Publishing AG, part of Springer Nature 2018.
About the journal
JournalData powered by TypesetOrthopedic Biomaterials: Progress in Biology, Manufacturing, and Industry Perspectives
PublisherData powered by TypesetSpringer International Publishing
Open AccessNo