Biomedical sensors provide an interface between the electrophysiological activity of different body organs and the instruments those facilitate an in-depth analysis of the pathological conditions. They constitute the most important part of a biomedical health monitoring system. Electrocardiogram (ECG), Photoplethysmogram (PPG), Blood pressure (BP) and respiration are the most fundamental cardiac and respiratory function indicators in a human body. This chapter is aimed to provide a brief overview of these sensors and interfacing techniques for digitized acquisition. © Springer International Publishing AG 2017.