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Biochemical studies on polychlorinated biphenyl toxicity in rats: Manipulation by vitamin C
D CHAKRABORTY, A BHATTACHARYYA, J CHATTERJEE, K CHATTERJEE, A SEN, S CHATTERJEE, K MAJUMDAR, G C CHATTERJEE
Published in -
1978
Volume: 48
   
Issue: 1
Pages: 22 - 31
Abstract
The effects of chronic polychlorinated biphenyl (PCB) compound toxicity on L-ascorbic acid metabolism in rats have been studied. PCB treatment brought about a depression in the activities of the enzymes L-gluonolactone oxidase and dehydroascorbatase along with an increased tissue levels and urinary excretion of L-ascorbic acid. PCB toxicity drastically disturbed the normal histological pattern of the liver cells and also significantly changed the hepatic lipid composition. L-ascorbic acid supplementation to the toxicated group of animals, although could not prevent the growth retardative effect of PCB, could afford a definite protection against the enzyme activity alterations and histological changes as caused by PCB toxicity.
About the journal
JournalInternational Journal for Vitamin and Nutrition Research
Publisher-
ISSN0300-9831