The reaction rate of Doebner condensation to achieve cinnamic acids can be dramatically enhanced by irradiating the reaction mixture containing an aromatic aldehyde, malonic acid, pyridine and a trace of piperidine with a commercial microwave oven. Ten cinnamic acids were synthesized within 2-5 min in excellent yields.
Topics: Malonic acid (53)%53% related to the paper, Aldehyde (51)%51% related to the paper and Pyridine (51)%51% related to the paper