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Anti arthritic and anti inflammatory activity of a cytotoxic protein NN-32 from Indian spectacle cobra (Naja naja) venom in male albino rats
A GOMES, P DATTA, T DAS, A K BISWAS, A GOMES
Published in Elsevier Ltd
2014
Volume: 90
   
Pages: 106 - 110
Abstract
The anti arthritic and anti inflammatory activity of NN-32, a cytotoxic protein from Indian spectacle cobra snake (Naja naja) venom has been studied in Freund's complete adjuvant (FCA) induced arthritis and carrageenan induced anti inflammatory model. NN-32 treatment showed significant decrease in physical and urinary parameters, serum enzymes, serum cytokines levels as compared to arthritic control group of rats. NN-32 treatment recovered carrageenan induced inflammation as compared to control group of rats. The findings showed that the cytotoxic protein NN-32 shares anti arthritic and anti inflammatory activity and thus NN-32 may target complex pathophysiological processes like cancer- arthritis-inflammation. © 2014 Elsevier Ltd. All rights reserved.
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JournalData powered by TypesetToxicon
PublisherData powered by TypesetElsevier Ltd
ISSN0041-0101