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An optimal multiarmed response adaptive design for survival outcome with independent censoring
Published in John Wiley and Sons Inc
2022
PMID: 34585751
Volume: 64
   
Issue: 1
Pages: 165 - 185
Abstract
Compromising ethics and precision in the context of a multiarmed clinical trial, an optimal order adjusted response adaptive design is proposed for survival outcomes subject to independent random censoring. The operating characteristics of the proposed design and the follow-up inference are studied both theoretically as well as empirically and are compared with those of the competitors. Applicability of the developed design is further illustrated through redesigning a real clinical trial with survival responses. © 2021 Wiley-VCH GmbH.
About the journal
JournalBiometrical Journal
PublisherJohn Wiley and Sons Inc
ISSN03233847