Header menu link for other important links
Amidation and Intramolecular Aza-Michael Reaction: One-Pot Synthetic Strategy of Isoindolinones
S. Asraf Ali, A. Bera, , S. Samanta
Published in John Wiley and Sons Inc
Volume: 6
Issue: 22
Pages: 5603 - 5609
Herein, we report one-pot Cu(I) catalyzed open flask synthetic strategy of 3-substituted N-pyridinyl isoindolinones from alkyl (E)-3-(2-formylphenyl)acrylate by oxidative amidation and intramolecular aza-Michael reaction using cheap air stable Cu(I) single catalyst. We have also established a synthetic route of N-aryl substituted isoindolinones with acid-amine coupling reaction of (E)-2-(3-alkoxy-3-oxoprop-1-en-1-yl)benzoic acid followed by aza-Michael reactions. Unexpected synthetic route of N-(1H-inden-1-yl)pyridin-2-amine derivatives have been documented from the same precursors using Cu(I) catalyst. © 2021 Wiley-VCH GmbH
About the journal
JournalData powered by TypesetChemistrySelect
PublisherData powered by TypesetJohn Wiley and Sons Inc