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Ameliorative effect of curry leaf aqueous extract against lead acetate-induced oxidative stress in rat kidneys
D GHOSH, S B FIRDAUS, E MITRA, A CHATTOPADHYAY, S K PATTARI, K JANA, D BANDYOPADHYAY,
Published in -
2013
Volume: 5
   
Pages: 546 - 556
Abstract
Objective: Aim of the study is to find therapeutic potentials of aqueous extract of Murraya koenigii (CuLE) against lead induced oxidative damage in renal tissues of rats. Methods: Rats were intraperitoneally (i.p.) injected with lead acetate (15mg/kg body weight), another group was pre-treated with CuLE (50 mg / kg, fed orally), the positive control group was fed CuLE (50 mg / kg), and the control animals received vehicle treatment (i.p.) for 7 consecutive days. Concentration of lead in renal tissue was quantified using AAS study. The changes in the activity of the different bio-markers of renal damage, biomarkers of oxidative stress, activities of the antioxidant and some of the mitochondrial enzymes were studied. Histomorphology was studied through H-E staining and alteration in tissue collagen level was studied through Sirius red staining and confocal imaging. Results: Lead acetate caused changes in all the parameters evaluated. All these changes were ameliorated when the rats were pre-treated with CuLE. Concentrations of lead in kidneys were also decreased following pre-treatment of rats with CuLE. Conclusion: CuLE has the potentiality to protect against lead acetate-induced oxidative stress mediated nephrotoxicity in rat possibly through its antioxidant activity. CuLE may have future therapeutic relevance in lead acetate-induced nephrotoxiity in human who are environmentally or occupationally exposed to lead.
About the journal
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Publisher-
ISSN0975-1491