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Ag(I)-Catalyzed Domino Cyclization-Addition Sequence with Simultaneous Carbonyl and Alkyne Activation as a Route to 2,2′-Disubstituted Bisindolylarylmethanes
S. Karmakar, P. Das, , S. Ghosh, S.K. Chattopadhyay
Published in American Chemical Society
2016
Volume: 18
   
Issue: 20
Pages: 5200 - 5203
Abstract
An efficient synthesis of symmetrical 3, 3′-bisindolylarylmethanes with various substituents on the indole moiety has been developed by Ag(I)-catalyzed cycloisomerization and an deoxygenative addition sequence on o-alkynylanilines and aryl aldehydes. Ag(I) is proposed to activate alkyne unit and carbonyl moiety simultaneously leading to a domino first 5-endo-dig indole annulation, addition to C=O, second indole annulation, and its dehydroxylative addition. © 2016 American Chemical Society.
About the journal
JournalData powered by TypesetOrganic Letters
PublisherData powered by TypesetAmerican Chemical Society
ISSN15237060