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Aggregation-Induced Emission-Based Sensing Platform for Selective Detection of Zn2+: Experimental and Theoretical Investigations
Published in Wiley-VCH Verlag
PMID: 30983076
Volume: 20
Issue: 12
Pages: 1630 - 1639
Fluorescent chemosensors with aggregation induced emission enhancement (AIEE) emerge as promising tools in the field of sensing materials. Herein, we report the design, synthesis and applicability of a Schiff base chemosensor 1-(benzo[1,3]dioxol-4-ylmethylene-hydrazonomethyl)-naphthalen-2-ol (Hbdhn) of AIE characteristics that exhibits highly effective and selective response towards Zn2+. The sensing effect of Hbdhn was evaluated by means of absorption/emission spectra and corresponding underlying photophysical mechanisms were proposed based on extensive quantum-chemical (TD)DFT calculations. The aggregated states in different DMSO/H2O ratios and in a presence of Zn2+ were examined by fluorescence lifetime measurements, dynamic light scattering and scanning electron microscopy studies. The bioimaging abilities of Hbdhn were evaluated for Zn2+ in HepG2 cancer cells. The results demonstrate instant, stable in time and reproducible, colorimetric turn-on response with superb selectivity and sensitivity of Hbdhn towards Zn2+, based on chelation enhanced fluorescence mechanism. AIEE improves further Hbdhn properties, leading to strong, long-lived fluorescence, with appearance of rod-like particles, in 90 % of water in DMSO and only 10 % of water in DMSO in the presence of Zn2+. All these features combined with successful biomaging studies make Hbdhn one of the most promising candidate for practical applications among recently proposed related systems. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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JournalData powered by TypesetChemPhysChem
PublisherData powered by TypesetWiley-VCH Verlag
Open AccessNo