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A traditional painkiller as a probe for microheterogeneity in 1-propanol-water mixtures
S CHAKRABORTY, E SEHANOBISH, M SARKAR
Published in ELSEVIER SCIENCE BV
2010
Volume: 501
   
Issue: 43468
Pages: 118 - 122
Abstract
Photo physical and spectral property of indomethacin has been harnessed to sense the cluster structures that exist at the microscopic level in binary mixtures of 1-propanol-water. The ability of indomethacin to switch from a fluorescent complex with alcohol self-association cluster at low water content, to a non-fluorescent complex with hydrogen-bonded water cluster at high water content, imparts the drug with its unique microheterogeneity sensing property. Similar results are obtained for methanol-water and 1-butanol-water binary mixtures. © 2010 Elsevier B.V. All rights reserved.
About the journal
JournalData powered by TypesetChemical Physics Letters
PublisherData powered by TypesetELSEVIER SCIENCE BV
ISSN0009-2614