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A terminally modified pseudopeptide (Gly-m-aminobenzoic acid) produces supramolecular helix, staircase and water-mediated β-sheet through self-assembly
A DUTT, S KAR, P KOLEY,
Published in Arkat
2009
Volume: 2009
   
Issue: 2
Pages: 31 - 43
Abstract
The pseudopeptide Gly-m-ABA (m-ABA = m-amino benzoic acid) has been chosen to study the formation of supramolecular structures through self-assembly. Single crystal X-ray diffraction studies reveal that the pseudopeptide Boc-Gly-m-ABA-OMe (1), where both N- and C-terminus are protected, self-assembles to a supramolecular helical structure, whereas the pseudopeptide Boc-Gly-m-ABA-OH (2) with free -CO2H at the C-terminus produces molecular staircase through self-assembly. Again the terminally unprotected pseudopeptide +NH3-Gly-m-ABA-CO2- (3) aggregates to a water mediated supramolecular β-sheet structure stabilized by intermolecular hydrogen bonds and π-π interactions. The study reveals that the terminally modified Gly-m-ABA generates various kinds of self-assembling building blocks that can fabricate different types of supramolecular architectures such as helix, β-sheet and staircase. © ARKAT USA, Inc.
About the journal
JournalArkivoc
PublisherArkat
ISSN1551-7012
Open AccessNo