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A simple, efficient and green procedure for the Knoevenagel condensation of aldehydes with N-methylpiperazine at room temperature under solvent-free conditions
Published in TAYLOR & FRANCIS INC
2008
Volume: 38
   
Issue: 13
Pages: 2103 - 2112
Abstract

Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions in the presence of N-methylpiperazine in excellent yields of the E-configured products. Copyright © Taylor & Francis Group, LLC.

About the journal
JournalSynthetic Communications
PublisherTAYLOR & FRANCIS INC
ISSN0039-7911
Open AccessNo