The rapid spread of COVID-19 pandemic has caused a severe disorder in the global economy. The sudden imposition of lockdown is expected to largely impact the global as well as Indian economy. To overcome serious economic fallouts, the honorable Prime Minister of India, Sri Narendra Modi in his address to the nation called for “Atmanirbhar Bharat Abhiyan” or “Self-reliant India” as self-reliance would help in making pragmatic developments of the economy. According to WHO, COVID-19 is a new strain found among humans that are caused by SARS-CoV-2, mainly a respiratory tract infection. As a consequence, the COVID-19 pandemic gives India a unique situation to face this period of crisis boldly for optimum utilization of the available resources, and shift towards a more resilient and sustainable economy. Attainment of self-reliance and sustainable resource management will also help the nation to overcome various global challenges. The present study mainly focuses on two objectives: Firstly, to understand the different possibilities which will secure India to become self-reliant; and secondly, to know the prospects of self-reliant of India in the post-COVID-19 scenario. It has to be kept in mind that Covid-19 may not be the last viral infection that the world might see. Therefore, Novel Coronavirus sets a distinctive chance for India and the countries alike to utilize the available resources strategically and transform its dreams of “local” India into “Glocal” India for a better and brighter future of her people. © 2021 John Wiley & Sons Ltd.