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A response-adaptive design in crossover trial
U BANDYOPADHYAY, A BISWAS, S MUKHERJEE
Published in TAYLOR & FRANCIS LTD
2012
Volume: 46
   
Issue: 5
Pages: 645 - 661
Abstract
In the present work, whenever the response variables are binary, we frame an adaptive allocation rule for a two-treatment two-period crossover design in the presence of possible carry-over effects. The proposed rule is a combination of the play-the-winner and randomized play-the-winner rules. We study various properties of the proposed rule through asymptotics and simulations. Some related inferential problems are also considered. The proposed procedure is compared with some possible competitor. © 2012 Copyright Taylor and Francis Group, LLC.
About the journal
JournalStatistics
PublisherTAYLOR & FRANCIS LTD
ISSN0233-1888