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A novel tryptamine-appended rhodamine-based chemosensor for selective detection of Hg 2+ present in aqueous medium and its biological applications
S HAZRA, C BODHAK, S CHOWDHURY, D SANYAL, S MANDAL, K CHATTOPADHYAY,
Published in Springer Verlag
2019
PMID: 30627799
Volume: 411
   
Issue: 6
Pages: 1143 - 1157
Abstract
A novel rhodamine–tryptamine conjugate–based fluorescent and chromogenic chemosensor (RTS) for detection of Hg 2+ present in water was reported. After gradual addition of Hg 2+ in aqueous methanol solution of RTS, a strong orange fluorescence and deep-pink coloration were observed. The probe showed high selectivity towards Hg 2+ compared to other competitive metal ions. The 1:1 binding stoichiometry between RTS and Hg 2+ was established by Job’s plot analysis and mass spectroscopy. Initial studies showed that the synthesized probe RTS possessed fair non-toxicity and effectively passed through cell walls of model cell systems, viz., human neuroblastoma (SHSY5Y) cells and cervical cells (HeLa) to detect intercellular Hg 2+ ions, signifying its utility in biological system. The limit of detection (LOD) was found to be 2.1 nM or 0.42 ppb by fluorescence titration. Additionally, the potential relevance of synthesized chemosensor for detecting Hg 2+ ions in environmental water samples has been demonstrated. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
About the journal
JournalData powered by TypesetAnalytical and Bioanalytical Chemistry
PublisherData powered by TypesetSpringer Verlag
ISSN1618-2642
Open AccessNo