A new neolignan designated (-)-maglifloenone and the known one futoenone, both of which contain the rarely occurring spirocyclohexadienone skeleton, have been isolated together with the tetrahydrofuranolignan (+)-veraguensin, an optically inactive tertiary base taspine and β-sitosterol from the leaves and twigs of Magnolia liliflora. The structure and stereochemistry of (-)-maglifloenone have been deduced from the spectral data and the mass fragmentation of (-)-maglifloenone and futoenone have been rationalized. This is the first report of two neolignans of spirocyclohexadienone skeleton and of taspine from the Magnoliaceae family and the second report of the natural occurrence of futoenone. © 1982.